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Ship with 5-10 days : Wolfgang R. Dostmann, Christian K. Nickl, in Handbook of Cell Signaling (Second Edition), 2010 ATP Binding Site-Targeted Inhibitors. Synthetic protein kinase inhibitors that are competitive with ATP and specific for PKA and/or PKG represent a structurally diverse group of small ligand compounds [24, 47].Polycyclic aromatics, such as isoquinolinesulfonyl and napthalenesulfonyl compounds (“H ChEBI Name KT 5720: ChEBI ID CHEBI:85085: Definition An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3-carboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling 2019-06-05 KT-5720 (108068-98-0) is a potent selective protein kinase A inhibitor: PKA (K i = 60 nM).
Sympatikusaktivering

It blocks PKA signaling through competitive inhibition of ATP with a K i value of 60 nM. 1 Reported IC 50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 µM (physiologic ATP).

This inhibition results in decreases in intracellular Ca2+ levels and suppression of dorsal root ganglion (DRG) neuron excitability.
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420320 Produktnamn: KT5720 REACH- registreringsnummer

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